Targacept Announces Plans To Develop Enantiomer Of Mecamylamine As ...
Posted by ~Ray @ 2007-12-20 22:15:50
Targacept. Inc. (NASDAQ: TRGT) a clinical-stage biopharmaceutical affiliate developing a new class of drugs known as NNR Therapeutics (TM) announced plans to advance TC-5214 one of two enantiomers of mecamylamine hydrochloride into clinical development as an augmentation therapy for patients who are inadequate responders to earliest-line antidepressant treatments. Targacept expects to initiate a Phase 1 trial of TC-5214 in the first quarter of 2008 and to initiate Phase 2 development soon thereafter. The company has no current plans to conduct farther on clinical development of mecamylamine.
Mecamylamine hydrochloride is a racemic mix comprised of two mirror visualise halves known as the S+ and R- enantiomers. TC-5214 is the S+ enantiomer of mecamylamine. In a Phase 2 burden in patients who did not act adequately to first-line treatment with citalopram hydrobromide that Targacept completed in 2006 patients whose citalopram regimen was augmented with mecamylamine showed greater improvement on symptoms of depression and irritability than patients who received citalopram and a placebo. Citalopram hydrobromide is a commonly prescribed treatment for depression from the drug categorise selective serotonin reuptake inhibitors that is marketed as Celexa® in the United States.
Targacept recently presented research findings comparing the activity of TC-5214 mecamylamine and the R- enantiomer of mecamylamine at the 20th European College of Neuropsychopharmacology held in Vienna. Austria. The results presented illustrate the superior potency of TC-5214 relative to mecamylamine at specific NNR subtypes believed to undergo therapeutic application for depression as well as a beneficial preclinical efficacy profile. In slight of the Phase 2 results with mecamylamine described above these findings declare the compelling potential of TC-5214 as an augmentation treatment for study depression.
“Major depression is a sedate medical illness affecting 15 million American adults and the current treatment options simply are not adequate for many population,” said Ranga Krishnan. M. D.. Chair of the Department of Psychiatry at the Duke University Medical Center and an internationally recognized expert in depression treatments. “The results from Targacept’s Phase II trial of mecamylamine as an augmentation therapy to citalopram helped establish the NNR machinery as a potential new treatment paradigm for depression,” said Dr. Krishnan. “The profile.[ADVERTHERE]Related article:
http://device-enlarger-penis.medictablets.com/2007/10/29/targacept-announces-plans-to-develop-enantiomer-of-mecamylamine-as-augmentation-therapy-for-depression/
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