Long-term Outcomes For Prostate Cancer Show Intensity Modulated ...
Posted by ~Ray @ 2008-03-12 23:18:37
Results from the largest study of men with prostate cancer treated with high-dose intensity modulated radiation therapy (IMRT) show that the majority of patients be alive with no evidence of disease after an average follow-up period of eight years. The 561 prostate cancer patients treated with IMRT at Memorial Sloan-Kettering Cancer Center were classified into prognostic risk groups. After an average of eight years. 89 percent of the men in the favorable assay group were disease-free and none of the men in any group developed secondary cancers as a result of the radiation therapy. This report published in the October 2006 issue of The Journal of Urology is the first of long-term outcomes for prostate cancer patients using IMRT.
“Our results suggest that IMRT should be the treatment of choice for delivering high-dose external beam radiotherapy for patients with localized prostate cancer,” said Dr. Michael J. Zelefsky. Chief of the Service at Memorial Sloan-Kettering. “We were able to show long-term safety and long-term efficacy in a very diverse group of prostate cancer patients that we followed — many for as long as ten years. Despite the fact that some patients had an aggressive form of their disease with high Gleason scores and PSA (prostate specific antigen) levels the overwhelming majority of patients had good tumor hold back with neither recurrence of their original cancer nor development of second cancers which one might undergo expected from the high doses of radiation,” he added. Pre-treatment diagnostic evaluations were performed for all of the patients to exceed be their clinically localized prostate cancer. They were classified into prognostic risk groups as defined by the National Comprehensive Cancer communicate guidelines (http://www nccn org). These are based on clinical characteristics including age. T stage. Gleason advance. PSA aim and pre-treatment with neoadjuvant androgen deprivation.
Between April 1996 and January 2000. 561 patients with a median age of 68 (ranging from 46 to 86 years old) were treated with IMRT an improved create of three-dimensional conformal radiation therapy (3D-CRT) also used in radiotherapy. IMRT uses enhanced planning treatment software that more precisely targets the prostate allowing the beam of radiation to deliver a high dose (81 Gy) to the tumor aim while sparing the adjacent bladder and rectum from exposure to the higher amounts of radiation. Perhaps because of this the eight-year results show urinary continence was maintained for all patients and only 1.6 percent of the five hundred sixty-one patients experienced rectal bleeding. The high-dose radiotherapy was curative for the majority of the patients in all three prognostic risk groups with 89 percent of the favorable. 78 percent of the intermediate and 67 percent of the unfavorable group alive after an average period of eight years. Of those men who were potent prior to IMRT erectile dysfunction developed in 49 percent.
“This study confirms that we can improve patients’ quality of life by reducing the side effects of radiotherapy while maintaining disease-free survival,” said Dr. Zelefsky. “However there is still room for improvement. We are incorporating approaches that may continue the excellent tumor control but further check the area we are irradiating and reduce side-effects.”
Memorial Sloan-Kettering Cancer Center is the world’s oldest and largest institution devoted to prevention patient compassionate research and education in cancer. Our scientists and clinicians generate innovative approaches to exceed understand analyse and treat cancer. Our specialists are leaders in biomedical investigate and in translating the latest research to go the standard of cancer care worldwide.[ADVERTHERE]Related article:
http://cellincpharmastem.myonlinepublication.com/2007/11/06/long-term-outcomes-for-prostate-cancer-show-intensity-modulated-radiation-therapy-curative/
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